Single blinded semi-field evaluation of MAÏA® topical repellent ointment compared to unformulated 20% DEET against Anopheles gambiae, Anopheles arabiensis and Aedes aegypti in Tanzania

Abstract Background N , -Diethyl-3-methylbenzamide (DEET) topical mosquito repellents are effective personal protection tools. However, DEET-based tend to have low consumer acceptability because they cosmetically unappealing. More attractive formulations needed encourage regular user compliance. This study evaluated the protective efficacy and duration of a new repellent ointment containing 15% DEET, MAÏA ® compared 20% DEET in ethanol using malaria dengue vectors Bagamoyo Tanzania. Methods Fully balanced 3 × Latin square design studies were conducted large semi-field chambers laboratory strains Anopheles gambiae sensu stricto arabiensis Aedes aegypti. Human volunteers applied either ointment, or their lower limbs 6 h before start tests. Approximately 100 mosquitoes per strain replicate released inside each chamber, with 25 at intervals during collection period maintain adequate biting pressure throughout test. Volunteers recaptured landing on for over 12-h post-application repellents. Data analysis was mixed-effects logistic regression. Results The not statistically different strains: 95.9% vs. 97.4% against An. (OR = 1.53 [95% CI 0.93–2.51] p 0.091); 96.8% vs 97.2% 1.08 0.66–1.77] 0.757); 93.1% 94.6% Ae. aegypti 0.76 0.20–2.80] 0.675). Average complete time (CPT) minutes that similar 571.6 min (95% 558.3–584.8) 575.0 562.1–587.9) ; 585.6 571.4–599.8) 580.9 571.1–590.7) 444.1 401.8–486.5) 436.9 405.2–468.5) Conclusions provides 9 both 7 (in ethanol). can be recommended as tool prevention outdoor tropical locations where majority people spend an ample going bed.